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    Inicio > Historias > Ensayos clínicos en Clinicaltrials.gov con uso de CRISPR 2019-12-23

    Ensayos clínicos en Clinicaltrials.gov con uso de CRISPR

    Decía en la ultima entrada de los 31 ensayos clínicos de clinicaltrials.gov  con la palabra CRISPR. Uno se retiró y de los 30 restantes he tenido referencia de resultados de los de CTX001 de anemia falciforme NCT03745287 y de betatalasemia NCT03655678 en Highly Efficient Therapeutic Gene Editing of Human Hematopoietic Stem Cells



    NCT Number

    Title

    Conditions

    Interventions

    Sponsor/Collaborators

    Phases

    Funded Bys

    URL

    NCT03057912

    A Safety and Efficacy Study of TALEN and CRISPR/Cas9 in the Treatment of HPV-related Cervical Intraepithelial Neoplasiaâ… 

    Human Papillomavirus-Related Malignant Neoplasm

    Biological: TALEN , Biological: CRISPR/Cas9

    First Affiliated Hospital, Sun Yat-Sen University , Jingchu University of Technology

    Phase 1

    Other

    https://ClinicalTrials.gov/show/NCT03057912

    NCT04074369

    Evaluation of CRISPR-based Test for the Rapid Identification of TB in Pulmonary Tuberculosis Suspects

    Tuberculosis, Pulmonary

    Diagnostic Test: CRISPR-based Test

    Huashan Hospital , Wenzhou Central Hospital , Hangzhou Red Cross Hospital

    Other

    https://ClinicalTrials.gov/show/NCT04074369

    NCT04178382

    Effect of PCR-CRISPR/Cas12a on the Early Anti-infective Schemes in Patients With Open Air Pneumonia

    Severe Sepsis

    Diagnostic Test: PCR-CRISPR/Cas12a detection

    Chinese Medical Association

    Not Applicable

    Other

    https://ClinicalTrials.gov/show/NCT04178382

    NCT03164135

    Safety of Transplantation of CRISPR CCR5 Modified CD34+ Cells in HIV-infected Subjects With Hematological Malignances

    HIV-1-infection

    Genetic: CCR5 gene modification

    Affiliated Hospital to Academy of Military Medical Sciences , Peking University , Capital Medical University

    Not Applicable

    Other

    https://ClinicalTrials.gov/show/NCT03164135

    NCT03545815

    Study of CRISPR-Cas9 Mediated PD-1 and TCR Gene-knocked Out Mesothelin-directed CAR-T Cells in Patients With Mesothelin Positive Multiple Solid Tumors.

    Solid Tumor, Adult

    Biological: anti-mesothelin CAR-T cells

    Chinese PLA General Hospital

    Phase 1

    Other

    https://ClinicalTrials.gov/show/NCT03545815

    NCT03655678

    A Safety and Efficacy Study Evaluating CTX001 in Subjects With Transfusion-Dependent β-Thalassemia

    Beta-Thalassemia , Thalassemia , Genetic Diseases, Inborn , Hematologic Diseases , Hemoglobinopathies

    Biological: CTX001

    Vertex Pharmaceuticals Incorporated , CRISPR Therapeutics

    Phase 1 , Phase 2

    Industry

    https://ClinicalTrials.gov/show/NCT03655678

    NCT03399448

    NY-ESO-1-redirected CRISPR (TCRendo and PD1) Edited T Cells (NYCE T Cells)

    Multiple Myeloma , Melanoma , Synovial Sarcoma , Myxoid/Round Cell Liposarcoma

    Biological: NY-ESO-1 redirected autologous T cells with CRISPR edited endogenous TCR and PD-1 , Drug: Cyclophosphamide , Drug: Fludarabine , Device: NY-ESO-1 expression testing

    University of Pennsylvania , Parker Institute for Cancer Immunotherapy , Tmunity Therapeutics

    Phase 1

    Other , Industry

    NCT04037566

    CRISPR (HPK1) Edited CD19-specific CAR-T Cells (XYF19 CAR-T Cells) for CD19+ Leukemia or Lymphoma.

    Leukemia Lymphocytic Acute (ALL) in Relapse , Leukemia Lymphocytic Acute (All) Refractory , Lymphoma, B-Cell , CD19 Positive

    Genetic: XYF19 CAR-T cell , Drug: Cyclophosphamide , Drug: Fludarabine

    Xijing Hospital , Xi'An Yufan Biotechnology Co.,Ltd

    Phase 1

    Other

    https://ClinicalTrials.gov/show/NCT04037566

    NCT03745287

    A Safety and Efficacy Study Evaluating CTX001 in Subjects With Severe Sickle Cell Disease

    Sickle Cell Disease , Hematological Diseases , Hemoglobinopathies

    Biological: CTX001

    Vertex Pharmaceuticals Incorporated , CRISPR Therapeutics

    Phase 1 , Phase 2

    Industry

    https://ClinicalTrials.gov/show/NCT03745287

    NCT04035434

    A Safety and Efficacy Study Evaluating CTX110 in Subjects With Relapsed or Refractory B-Cell Malignancies

    B-cell Malignancy , Non-Hodgkin Lymphoma , B-cell Lymphoma

    Biological: CTX110

    CRISPR Therapeutics AG , CRISPR Therapeutics

    Phase 1 , Phase 2

    Industry

    https://ClinicalTrials.gov/show/NCT04035434

    NCT03538613

    Study of People With Metastatic Gastrointestinal Epithelial Cancer Administering Tumor-Infiltrating Lymphocytes in Which the Gene Encoding CISH Was Inactivated Using the CRISPR/Cas9 System

    Gastrointestinal Epithelial Cancer , Gastrointestinal Neoplasm , Cancer of Gastrointestinal Tract , Cancer, Gastrointestinal

    Drug: Cyclophosphamide , Drug: Fludarabine , Drug: Aldesleukin , Biological: CISH inactivated TIL

    National Cancer Institute (NCI) , National Institutes of Health Clinical Center (CC)

    Phase 1 , Phase 2

    NIH

    https://ClinicalTrials.gov/show/NCT03538613

    NCT03728322

    iHSCs With the Gene Correction of HBB Intervent Subjests With β-thalassemia Mutations

    Thalassemia

    Biological: iHSCs treatment group

    Allife Medical Science and   Technology Co., Ltd.

    Early Phase 1

    Industry

    https://ClinicalTrials.gov/show/NCT03728322

    NCT03747965

    Study of PD-1 Gene-knocked Out Mesothelin-directed CAR-T Cells With the Conditioning of PC in Mesothelin Positive Multiple Solid Tumors

    Solid Tumor, Adult

    Biological: Mesothelin-directed CAR-T cells

    Chinese PLA General Hospital

    Phase 1

    Other

    https://ClinicalTrials.gov/show/NCT03747965

    NCT03855631

    Exploiting Epigenome Editing in Kabuki Syndrome: a New Route Towards Gene Therapy for Rare Genetic Disorders

    Kabuki Syndrome 1

    Genetic: Intervention on primary cultured cells

    University Hospital, Montpellier , Association Française contre les Myopathies Telethon

    Other

    https://ClinicalTrials.gov/show/NCT03855631

    NCT03342547

    Identification of Host Factors of Norovirus Infections in Mini-Gut Model

    Gastrointestinal Infection

    Procedure: Duodenal biopsy , Procedure: Saliva

    Chinese University of Hong Kong

    Not Applicable

    Other

    https://ClinicalTrials.gov/show/NCT03342547

    NCT03166878

    A Study Evaluating UCART019 in Patients With Relapsed or Refractory CD19+ Leukemia and Lymphoma

    B Cell Leukemia , B Cell Lymphoma

    Biological: UCART019

    Chinese PLA General Hospital

    Phase 1 , Phase 2

    Other

    https://ClinicalTrials.gov/show/NCT03166878

    NCT03606486

    Lavage of the Uterine Cavity for Diagnosis of Ovarian Cancer

    High Grade Ovarian Serous Adenocarcinoma , Stage III Ovarian Cancer AJCC v8 , Stage IIIA Ovarian Cancer AJCC v8 , Stage IIIA1 Ovarian Cancer AJCC v8 , Stage IIIA2 Ovarian Cancer AJCC v8 , Stage IIIB Ovarian Cancer AJCC v8 , Stage IIIC Ovarian Cancer AJCC v8 , Stage IV Ovarian Cancer AJCC v8 , Stage IVA Ovarian Cancer AJCC v8 , Stage IVB Ovarian Cancer AJCC v8

    Other: Biospecimen Collection , Other: Laboratory Biomarker Analysis , Other: Lavage , Other: Pap Smear

    University of Washington , National Cancer Institute (NCI) , Minnesota Ovarian Cancer Alliance

    Not Applicable

    Other , NIH

    https://ClinicalTrials.gov/show/NCT03606486

    NCT03398967

    A Feasibility and Safety Study of Universal Dual Specificity CD19 and CD20 or CD22 CAR-T Cell Immunotherapy for Relapsed or Refractory Leukemia and Lymphoma

    B Cell Leukemia , B Cell Lymphoma

    Biological: Universal Dual Specificity CD19 and CD20 or CD22 CAR-T Cells

    Chinese PLA General Hospital

    Phase 1 , Phase 2

    Other

    https://ClinicalTrials.gov/show/NCT03398967

    NCT03081715

    PD-1 Knockout Engineered T Cells for Advanced Esophageal Cancer

    Esophageal Cancer

    Other: PD-1 Knockout T Cells

    Hangzhou Cancer Hospital , Anhui Kedgene Biotechnology Co.,Ltd

    Not Applicable

    Other

    https://ClinicalTrials.gov/show/NCT03081715

    NCT03332030

    Stem Cells in NF1 Patients With Tumors of the Central Nervous System

    Neurofibromatosis Type 1 , Tumors of the Central Nervous System

    Diagnostic Test: Collection of Stem Cells

    Children's Research Institute

    Other

    https://ClinicalTrials.gov/show/NCT03332030

    NCT03690011

    Cell Therapy for High Risk T-Cell Malignancies Using CD7-Specific CAR Expressed On Autologous T Cells

    T-cell Acute Lymphoblastic Leukemia , T-cell Acute Lymphoblastic Lymphoma , T-non-Hodgkin Lymphoma

    Genetic: CD7.CAR/28zeta CAR T cells , Drug: Fludarabine , Drug: Cytoxan

    Baylor College of Medicine , The Methodist Hospital System , Texas Children's Hospital , Center for Cell and Gene Therapy, Baylor College of Medicine

    Phase 1

    Other

    https://ClinicalTrials.gov/show/NCT03690011

    NCT03681951

    First-time-in-human (FTIH) Study of GSK3145095 Alone and in Combination With Other Anticancer Agents in Adults With Advanced Solid Tumors

    Neoplasms, Pancreatic

    Drug: GSK3145095 , Drug: Pembrolizumab

    GlaxoSmithKline , Parexel

    Phase 2

    Industry

    https://ClinicalTrials.gov/show/NCT03681951

    NCT02863913

    PD-1 Knockout Engineered T Cells for Muscle-invasive Bladder Cancer

    Invasive Bladder Cancer Stage IV

    Biological: PD-1 Knockout T Cells , Drug: Cyclophosphamide , Drug: IL-2

    Peking University

    Phase 1

    Other

    https://ClinicalTrials.gov/show/NCT02863913

    NCT02867345

    PD-1 Knockout Engineered T Cells for Castration Resistant Prostate Cancer

    Hormone Refractory Prostate Cancer

    Biological: PD-1 Knockout T Cells , Drug: Cyclophosphamide , Drug: IL-2

    Peking University

    Other

    https://ClinicalTrials.gov/show/NCT02867345

    NCT02867332

    PD-1 Knockout Engineered T Cells for Metastatic Renal Cell Carcinoma.

    Metastatic Renal Cell Carcinoma

    Biological: PD-1 Knockout T Cells , Drug: Cyclophosphamide , Drug: IL-2

    Peking University

    Phase 1

    Other

    https://ClinicalTrials.gov/show/NCT02867332

    NCT02793856

    PD-1 Knockout Engineered T Cells for Metastatic Non-small Cell Lung Cancer

    Metastatic Non-small Cell Lung Cancer

    Drug: Cyclophosphamide , Other: PD-1 Knockout T Cells

    Sichuan University , Chengdu MedGenCell, Co., Ltd.

    Phase 1

    Other , Industry

    https://ClinicalTrials.gov/show/NCT02793856

    NCT03044743

    PD-1 Knockout EBV-CTLs for Advanced Stage Epstein-Barr Virus (EBV) Associated Malignancies

    Stage IV Gastric Carcinoma , Stage IV Nasopharyngeal Carcinoma , T-Cell Lymphoma Stage IV , Stage IV Adult Hodgkin Lymphoma , Stage IV Diffuse Large B-Cell Lymphoma

    Drug: Fludarabine , Drug: Cyclophosphamide , Drug: Interleukin-2

    Yang Yang , The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School

    Phase 1 , Phase 2

    Other

    https://ClinicalTrials.gov/show/NCT03044743

    NCT03872479

    Single Ascending Dose Study in Participants With LCA10

    Blindness , Leber Congenital Amaurosis 10 , Vision Disorders , Eye Diseases , Eye Diseases, Hereditary , Eye Disorders Congenital , Retinal Disease , Retinal Degeneration

    Drug: AGN-151587

    Allergan , Editas Medicine, Inc.

    Phase 1 , Phase 2

    Industry

    https://ClinicalTrials.gov/show/NCT03872479

    NCT04122742

    Diagnosis of RSTS: Identification of the Acetylation Profiles as Epigenetic Markers for Assessing Causality of CREBBP Variants.

    Rubinstein-Taybi Syndrome

    Procedure: skin biopsy for the primary fibroblast culture and a 15 ml blood sample (3 unnamed samples of 5ml) in each of the 4 SRT patients included. , Other: Generation of Induced Pluripotent Stem Cells (iPSC) from fibroblasts obtained by skin biopsy , Other: Histone acetylation profiles of cells of SRT patients with CREBBP mutations , Other: Functional involvement of identified epigenetic alterations , Biological: Culture of lymphoblastoid line from blood sample

    University Hospital, Bordeaux

    Other

    https://ClinicalTrials.gov/show/NCT04122742

    NCT02964481

    Malignant Hyperthermia Registry and Genetic Testing

    Malignant Hyperthermia

    Children's Hospital Medical Center, Cincinnati

    Other

    https://ClinicalTrials.gov/show/NCT02964481


    2019-12-23 07:26 | 0 Comentarios


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